Total Synthesis of (+)-Penicyclone A and Evaluation of Biological Activity Including Intermediate Compounds

Mirko Duvnjak; Gregor Talajić; Jurica Baranašić; Nea Baus Topić; Hana Čipčić Paljetak; Nikola Cindro Penicyclone A is a polyketide compound with a unique and intriguing structure recently isolated from the fungus Penicillium sp. F23-2 during an OSMAC (one-strain-many-compounds) campaign. The compound demonstrated significant antimicrobial activity without exhibiting any cytotoxic effects, which prompted us to pursue […]